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Translational and Clinical Research (TCR) Flagship Programme

The aim of the Translational and Clinical Research (TCR) Flagship programme is to establish Singapore as a leader in a number of strategic disease-oriented areas by supporting research that facilitates the translation of basic scientific advances into clinical applications through the integration, coordination and leverage of the full chain of research capabilities.

The programme seeks to integrate, coordinate and leverage research from basic science to clinical research, in the following identified five disease areas: Cancer, Cardiovascular/Metabolic Disorders, Neurosciences, Infectious diseases, and Eye diseases.

Moreover, this programme helps to build up a critical mass of excellent researchers in the five areas mentioned above. This will also position Singapore as a leader in scientific and medical research, in addition to improving the quality of clinical care. It will in turn attract more foreign patients to seek care in Singapore, and also attract biotech, medical devices and pharmaceutical companies to relocate here.

The TCR Flagship Programme is funded by the National Research Foundation (NRF) with a budget of S$25 million for each disease area over 5 years.

Researchers, clinicians and clinician scientists working in one of the above strategic areas are all applicable for this award. The proposed programme has to be integrative and demonstrate a strong collaborative nature. It also has to be scientifically competitive with the potential of being a leader in its field internationally. All applications will be evaluated by the TCR Flagship Review Committee comprising of local and international members. Short-listed applicants would have to submit a more detailed proposal for review by international experts before a final evaluation by the TCR Flagship Review Committee.

Since 2007, through 3 grant calls, all of the five TCR flagship programmes have been awarded to the following teams.

DiseaseTitle
Lead PI
Host Institution
Year of Award
Cancer

The Singapore Gastric Cancer Consortium - Improving Outcomes for Our Patients

Yeoh Khay Guan
NUS
Aug 2007
Neuroscience
Vulnerability, Disease Progression, and Treatment in Schizophrenia and Related Psychoses

Chong Siow Ann
IMH
Jul 2008
Eye Diseases
Singapore Eye Research Institute TRIOS Programme (Translational Research Innovations in Ocular Surgery)

Donald Tan 
SERI
Jul 2008
Cardiovascular/ Metabolic Diseases

Developmental Pathway to metabolic diseases

Chong Yap Seng
NUS
Dec 2008
Infectious Disease
Scientific exploration, translational research, operational evaluation of disease prevention and preventative measures through new treatment strategies against Dengue (STOP Dengue)

Leo Yee Sin
TTSH
Dec 2008

 

The abstracts of the awarded five programmes can be found at the following links:

1. Cancer
2. Cardiovascular / Metabolic Disorders
3. Neurosciences
4. Infectious Diseases
5. Eye Diseases