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Translational and Clinical Research (TCR) Flagship Programme

TCR Flagship Programmes provide significant levels of funding to build up a critical mass of experienced high-level researchers to facilitate a broader research platform, and increase collaboration both locally and internationally. These programmes aim to establish Singapore as a global leader in the study of key strategic medical research fields by integrating, coordinating and leveraging the full spectrum of research capabilities in Singapore from basic science to clinical research in a comprehensive manner.

The TCR Flagship Programme grant was launched as a strategic initiative in BMS initiative Phase II (spanning from Years 2006 – 2010) to bring together the best complementary research strengths in hospitals and national disease centres, universities and A*STAR Research Institutes to focus on disease or research themes of strategic importance. Individual programmes can receive up to a maximum of S$25M in funding, inclusive of indirect costs, and must be led by a well-qualified clinician-scientist, who served as the Lead Principal Investigator. Three thematic grant calls were conducted and led to the funding of five programmes in the niche areas of Gastric Cancer (Oncology), Eye Diseases, Schizophrenia (Neuroscience), Dengue (Infectious Diseases) and Metabolic Diseases. All five programmes were funded by the National Research Foundation (NRF).

Since its inception in 2007, the TCR Flagship Programme Grant has been revised to match the needs of Singapore’s research landscape in BMS Initiative Phase III (spanning from Years 2011 – 2015). One of the key changes is the grant funding structure. Unlike the previous tranche, the new TCR Flagship Programme Grant, offers two tiers of funding for over 5 years, to provide existing programmes renewal opportunities and to allow for the funding of new programmes.

-       Tier 1 which is capped at S$9M inclusive of indirect cost and;

-       Tier 2 which is capped at S$25M inclusive of indirect cost,

The new programmes will continue to be funded by the National Research Foundation (NRF). Funds will be drawn from the Research, Innovation and Enterprise (RIE) 2015 Open Collaborative Fund (OCF) budget where S$175M is allocated for the TCR Flagship Programmes.

The first, of a series of three grant calls scheduled for RIE 2015, was launched in December 2011. It was an open grant call and a total of four awards- two Tier 1, which are new programmes, and two Tier 2, which are renewal applications- were given out. All four programmes were featured in the 9 Nov 2012 press release for the BMS International Advisory Committee (IAC) Meeting chaired by Sir Richard Sykes in November 2012.

The following table is the latest list of TCR Flagship Programmes funded by NMRC.

 

S/N

Title

Disease Area of Research

Lead PI

Host Institution

Year of Award

Amount Awarded (incl. IRC)

BMS Phase II Programmes

1

The Singapore Gastric Cancer Consortium - Improving Outcomes for Our Patients

Oncology- Gastric Cancer

Yeoh Khay Guan

NUS

Aug 2007

S$25M

2

Vulnerability, Disease Progression, and Treatment in Schizophrenia and Related Psychoses

Neuroscience- Schizophrenia

Chong Siow Ann

IMH

Jul 2008

S$25M

3

Singapore Eye Research Institute TRIOS Programme (Translational Research Innovations in Ocular Surgery)

Eye Diseases

Donald Tan 

SERI

Jul 2008

S$25M

4

Developmental Pathway to metabolic diseases

Metabolic Diseases

Chong Yap Seng

NUS

Dec 2008

S$25M

5

Scientific exploration, translational research, operational evaluation of disease prevention and preventative measures through new treatment strategies against Dengue (STOP Dengue)

Infectious Diseases- Dengue

Leo Yee Sin

TTSH

Dec 2008

S$25M

BMS Phase III Programmes

6

Genetic Predilection, Epigenetic Change, MicroRNA Profiling and  Experimental Therapies in Heart Failure

Cardiovascular Disease

Mark Richards

NUHS

Jan 2013

Tier 1- S$9M

 

7

Non-Small Cell Lung Cancer: Targeting Cancer Stem Cell and Drug Resistance

Oncology- Lung Cancer

Tan Eng Huat

NCC

Jan 2013

Tier 1- S$9M

 

8

Eye Surgery and Innovative Technologies (EyeSITe)

Eye Diseases

Donald Tan

SERI

Jan 2013

Tier 2- S$25M

9

Singapore Gastric Cancer Consortium- Re-defining Gastric Cancer Management

Oncology- Gastric Cancer

Yeoh Khay Guan

NUHS

Jan 2013

Tier 2- S$25M

Note: all programmes are new unless indicated otherwise. Abstract is available via the hyperlink accessible from the title of the programme.