| Application ID |
Project Title |
Institution |
Name |
| BNIG11nov001 |
Using a HAT (histone acetyltransferase) to pull a trick on cancer |
NUHS |
Jha, Sudhakar |
| BNIG11nov003 |
Genetic regulation of dopamine neuron integrity, Drosophila and human studies. |
NNI |
Tio, Murni |
| BNIG11nov004 |
Role of phosphatidylinositol 3-kinase signaling pathway in cell proliferation during radiotherapy: a mechanistic study on lung cancer and normal cell repopulation |
NCC |
Baskar, Rajamanickam |
| BNIG11nov008 |
Investigation of a Novel Stress Repressor, CReP in Human Renal Cell Carcinomas |
Duke-NUS |
ZHOU, Wei |
| BNIG11nov010 |
Defining the function of ERI3 in DENV replication and selection of RNA aptamers that inhibit ERI3 activity |
Duke-NUS |
Ward, Alex Michael |
| BNIG11nov011 |
Phosphatases as potential regulators of LRRK2-induced neurotoxicity |
NNI |
Lin, Shuping |
| BNIG11nov014 |
Brugada Syndrome: An in vitro humanized disease modeling with iPSC approach |
NHC |
Mehta, Ashish |
| BNIG11nov018 |
Modulation of Ras-induced autophagy via genetic and pharmacological targeting of CK1α: a novel anti-cancer strategy. |
Duke-NUS |
Cheong, Jit Kong |
| BNIG11nov019 |
Survey of human host factors modulating the activity of HIV integration complex using a newly developed high-throughput protein screening system |
NUHS |
Suzuki, Yoichi |
| BNIG11nov020 |
A human ocular surface disease constituted in mouse, from molecular targets to priming of human pterygium derived cells. |
SERI |
Hou, Aihua |
| BNIG11nov021 |
Neural Causes of Cognitive Decision Making |
Duke-NUS |
Hsieh, Po-Jang |
| CBRG11nov006 |
Elucidating the role of Zfp553 in ES cell Identity and reprogramming |
NUHS |
Wu, Qiang |
| CBRG11nov012 |
Development of novel fluorescent probes for detection and isolation of human lung cancer stem cells and for in vivo cancer imaging |
NUHS |
Chang, Young-Tae |
| CBRG11nov015 |
Blood flow in the microcirculation: Influences of hemorheological disorders |
NUHS |
Kim, Sangho |
| CBRG11nov019 |
The zebrafish liver cancer models for rapid in vivo testing of cancer gene potency and anti-cancer drug discovery |
NUHS |
Gong, Zhiyuan |
| CBRG11nov032 |
Development of Andrographolide As Novel Therapy for Chronic Obstructive Pulmonary Disease |
NUHS |
Wong, Wai Shiu Fred |
| CBRG11nov033 |
Functional analysis of the c-Jun-N-terminal kinase 1 (JNK1)-SIRT1 interaction – directly or indirectly through the novel JNK1/deleted in breast cancer-1 (DBC1) interaction – from molecular characterization to pre-clinical testing |
NCC |
Sabapathy, Kanaga |
| CBRG11nov034 |
Role of G9a in skeletal myogenesis and muscular dystrophy |
NUHS |
Taneja, Reshma |
| CBRG11nov036 |
Single cell genomics, a new window into malaria parasite physiology and pathogenicity. |
NTU |
Bozdech, Zbynek |
| CBRG11nov050 |
Tissue Engineering of the Intervertebral Disc - Regenerating the Annulus Fibrosus with Electrospinning and Physiologically Mimetic Culture. |
NUHS |
Toh, Siew Lok |
| CBRG11nov054 |
Validating candidate biomarkers in plasma microvesicles for the diagnosis and prognosis of lacunar infarction |
NTU |
Sze, Siu Kwan |
| CBRG11nov055 |
Biochemical Mechanisms of Triglyceride Droplet Formation |
Duke-NUS |
Silver, David L. |
| CBRG11nov060 |
Applications of Semiparametric Regression Models in Prospective Cohort Studies |
SERI |
Li, Jialiang |
| CBRG11nov067 |
Scaffold-mediated RNA interference to enhance remyelination and nerve regeneration in traumatic nerve injuries |
NTU |
Chew, Sing Yian |
| CBRG11nov075 |
Identifying novel genes underlying tumorigenesis in retinoblastoma beyond loss of RB1 |
NUHS |
Lai, Poh San |
| CBRG11nov081 |
Establishing the feasibility of targeting the non-structural protein 1 of influenza A virus for the development of a novel and broad-spectrum antibody-based immunotherapy |
NUHS |
Tan, Yee Joo |
| CBRG11nov083 |
Novel antagonists of nicotinic acetylcholine receptors and understanding of specific pharmacophores |
NUHS |
Kini, R. Manjunatha |
| CBRG11nov085 |
Targeting Assembly and Function of Hepatitis C Virus Replicase |
NTU |
Cho, Nam-Joon |
| CBRG11nov086 |
Role of tight junction proteins in adaptive and innate immunity |
NTU |
Ruedl, Christiane |
| CBRG11nov091 |
Comprehensive chromosome-wide allele-specific analyses of X chromosome inactivation |
NTU |
Zhang, Li-Feng |
| CBRG11nov095 |
Membrane trafficking in mTOR signaling and autophagy - the roles of Golgi localized ARF-like GTPases |
NTU |
Lu, Lei |
| CBRG11nov097 |
Novel Drug Targets for Gastric Cancer Therapy |
NUHS |
Lim, Yoon Pin |
| CBRG11nov098 |
Understanding the relevance of p73 regulation by hypoxia |
NCC |
Sabapathy, Kanaga |
| CBRG11nov101 |
Regulatory mechanisms of MAPK phosphatase 5 in metabolic disorders |
NUHS |
Zhang, Yongliang |
| CBRG11nov104 |
Quantitative Proteomic Analysis of Gastric Fluid for Biomarker Discovery and Development of Multiple Reaction Monitoring Assays for Clinical Applications |
NCC |
Ho, Meng Fatt |
| CBRG11nov105 |
Interaction between Galectin-1 and L-type CaV1.2 Calcium Channel Splice Variants: Implications in Vascular Hypertension |
NUHS |
Soong, Tuck Wah |
| CBRG11nov109 |
Development of Therapeutic Microbes for Prevention and Treatment of Infectious Disease |
NTU |
Chang, Matthew Wook |
| CBRG11nov114 |
Targeting proteome homeostasis: a new approach to antimycobacterial drug discovery |
NUHS |
Dick, Thomas |
| CIRG11nov013 |
Hematopoietic stem cell-specific imaging, transgenesis and gene targeting |
NUHS |
Osato, Motomi |
| CIRG11nov019 |
Study the mechanisms underlying the pro-survival effect of Bcl-2-Rac1 interaction in cancer cells and primary tissue from clinical lymphomas and to elucidate the role of STAT3 in this signaling network |
NUHS |
Pervaiz, Shazib |
| CIRG11nov024 |
Nitric oxide synthase inhibition in cancer patients: phase I trial of L-NNA and biomarker devlopment |
NCC |
Ng, Quan Sing |
| CIRG11nov025 |
Image-guided simultaneous fingerprint and high wavenumber Raman spectroscopy for improving in vivo diagnosis and detection of nasopharyngeal and laryngeal cancer during clinical endoscopy |
NUHS |
Huang, Zhiwei |
| CIRG11nov029 |
A study to determine whether cytokine gene therapy can improve the efficacy and toxicity of Bacillus Calmette Guerin (BCG) immunotherapy for bladder cancer |
NUHS |
Esuvaranathan, Kesavan |
| CIRG11nov040 |
PBRM1, a novel therapeutic target for kidney cancer – from drug discovery to mouse model. |
Duke-NUS |
Teh, Bin Tean |
| CIRG11nov045 |
Pyrosequencing assay for early detection of hepatitis B virus (HBV) drug resistant mutants in chronic HBV patients on antiviral therapy |
NUHS |
Lee, Guan Huei |
| CIRG11nov050 |
Randomized clinical trial of Epstein-Barr virus-specific autologous cytotoxic T lymphocytes for the treatment of advanced nasopharyngeal carcinoma patients |
NCC |
Toh, Han Chong |
| CIRG11nov053 |
Prophylactic laser iridotomy for eyes with narrow drainage angles: A randomized controlled trial |
SERI |
Aung, Tin |
| CIRG11nov062 |
Translating the Role of Aspergillus Galactomannan in Pathogenesis and Optimization of Diagnostic Capability in Invasive Fungal Infection |
NUHS |
Chai, Louis |
| CIRG11nov065 |
To define the role of phosphatidic acid-preferred phospholipase A1 in glucosestimulated insulin secretion in pancreatic beta-cells |
SGH |
Li, GuoDong |
| CIRG11nov068 |
Identification of Drugs for Targeted Treatment of PTEN-Deficient Tumors |
Duke-NUS |
Rozen, Steven George |
| CIRG11nov070 |
Zinc finger nuclease-mediated transgenesis for autologous cell therapy of hemophilia A |
NCC |
Kon, Oi Lian |
| CIRG11nov071 |
AN IMMUNIZATION STRATEGY TO PREVENT HEPATOCELLULAR CARCINOMA |
NCC |
Ooi, Peng Jin London Lucien |
| CIRG11nov074 |
ST3Gal1 sialyltransferase mediates invasiveness and tumorigenicity in gliomapropagating cells and associates with patient survival outcome and disease progression |
NNI |
Ang, Beng Ti Christopher |
| CIRG11nov081 |
Potential role of Branched Chain Amino Acids in the development of insulin resistance and involvement of lifestyle, anthropometric and genetic factors |
NUHS |
Lee, Jen Mai Jeannette |
| CIRG11nov084 |
Development of therapeutic approaches to overcome drug resistance conferred by a novel BIM deletion polymorphism in chronic myelogenous leukemia and EGFR-mutated non-small-cell lung cancer |
Duke-NUS |
Ong, Sin Tiong |
| CIRG11nov087 |
A Brain-Computer Interface Based Intervention versus Sham Intervention for the Treatment of ADHD - a Double-Blind Randomized Controlled Trial |
Duke-NUS |
Lee, Tih Shih |
| CIRG11nov094 |
Safety and efficacy of blocking IL-4 in patients receiving standard combination therapy for pulmonary tuberculosis (TB): a randomized, double-blind, placebo-controlled, proof-of-concept clinical trial |
NUHS |
Paton, Nicholas |
| CNIG11nov008 |
Studying the mechanisms of Negative Pressure Wound Therapy (NPWT) in aiding wound healing and its possible link towards cancer progression |
NUHS |
Puhaindran, Mark Edward |
| CNIG11nov012 |
Birth parameters, early life course factors, and associations with myopia in young children [GUSTO-EYE]. |
NUHS |
Ngo, Shufen Cheryl |
| CNIG11nov029 |
Elucidating the role of Phosphodiesterase 4D (PDE4D) inhibitors in cancer |
NUHS |
Chan, Boon Yeow Daniel |
| CNIG11nov031 |
The prevalence and natural history of cow milk and hen’s egg allergy in an Asian population - impact of component resolved diagnostic tests in predicting severity and natural history |
NUHS |
Lee, Alison Joanne |
| CNIG11nov032 |
Evaluation of the significance and clinical utility of soluble CD137 and soluble CD137 ligand in monitoring and treating rheumatoid arthritis |
NUHS |
CHEUNG, Peter Pak Moon |
| CNIG11nov035 |
Development of Biomarkers for Contrast Enhanced Endoscopy in Gastric Cancer |
NUHS |
Anand Devaprasath, Jeyasekharan |
| CNIG11nov038 |
Understanding Role and Molecular Mechanism of LIN28B-Let-7 microRNA Regulatory Axis in Leukemia Stem Cell |
NUHS |
Zhou, Jianbiao |
| CNIG11nov040 |
Novel cellular substrate for complement protease C1s: implications in the pathogenesis of systemic lupus erythematosus (SLE |
KKH |
Yeo, Joo Guan |
| CNIG11nov043 |
Identification and functional characterization of novel microRNAs associated with liver cancer epithelial-mesenchymal transition, recurrence, metastasis and chemoresistance |
NCC |
Xia, Hongping |
CSANOV11-001
|
Targeting Adipose Tissue Function for Prevention and Treatment of Type 2 Diabetes via Study of FIT FAT (Families with Inherited Traits for Functional Adipose Tissue) |
NUH |
Sue-Anne Toh Ee Shiow |
CSANOV11-002
|
Singapore Age-related macular degeneration Genetic Architecture (SAGA) Study: from Population Genomics to Personalized Medicine |
NUHS |
Cheng Ching-Yu |
CSANOV11-003
|
A Hybrid Approach to Nanoparticle Design Integrating Protein-Engineered, Disease-Responsive Nanoshells with Biocompatible Polymeric Cores |
NUH |
Chester Lee Drum |
CSANOV11-007
|
Retinal Vascular Imaging Study in Transient Ischemic Attacks (REVISTA) |
SERI |
Mohammad Kamran Ikram |
CSANOV11-009
|
Investigations into the role of Short Chain Fatty Acids in Myeloid Derived Suppressor Cell Biology in Crohn's Disease Patients |
SGH |
Ling Khoon Lin |
CSANOV11-014
|
Novel statistical methods for analysis of complex clinical, serological and biological data in vaccine research |
Duke-NUS |
Cheung Yin Bun |
CSANOV11-015
|
A Randomised Clinical Trial for Evaluating the Safety and Feasibility of Intensive Lowering of Blood Pressure in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis |
NUHS |
Vijay Sharma Kumar |
| TA/004/2011 |
Novel Biomarkers of Atherosclerosis and Myocardial Damage for the Detection of Sub-Clinical Coronary Artery Disease and Prediction of Myocardial Infarction in Singapore Chinese |
NHCS |
Reginald Liew |
| TA/008/2011 |
Analysis of blood-based biomarkers in first episode psychosis |
IMH |
Jimmy Lee Chee Keong |
| TA/009/2011 |
Investigating efficacy and safety of the dual approaches of intrauterine gene transfer and haematopoietic stem cell transplant for fetal treatment of thalassaemia major in a knock-out murine model |
NUHS |
Citra Nurfarah binte Zaini Mattar |
| TA/011/2012 |
Viral Mediators of HIV-Associated Osteoporosis |
NUHS |
Nicholas CHEW Sern Yan |
| TA/012/2011 |
Dissecting the Complexity and Heterogeneity in Epithelial Ovarian Cancer: The Emergence of Personalized Medicine Utilizing the Concept of Epithelial-mesenchymal Transition |
NUHS |
Ruby Yun-Ju Huang |
| TA/013/2011 |
To study the combination of a-galactosylceramide-based NKT and BCG immunotherapy in high risk superficial bladder cancer |
SGH |
Chong Tsung Wen |
| TA/014/2012 |
Concurrent validity of biochemical biomarkers associated with cartilage morphological change in patients with early osteoarthritis |
SGH |
Leung Ying Ying |
| TA/016/2012 |
Novel Biomarkers of Kidney and Eye Diseases (Singapore Kidney Eye Study) |
SERI |
Charumathi Sabanayagam |
TA/018/2011
|
The difference in HIV-1 clinical progression between CRF01_AE and subtype B is potentially due to differences in the env gene and independent of HIV-1 viral load |
TTSH |
Ng Oon Teck |
Applying For Grants