Abstract of TCR Infectious Disease Programme
Title: Scientific exploration, Translational research, Operational evaluation of disease prevention and Preventative measures through new treatment strategies against Dengue (STOP Dengue) Programme
Dengue fever/dengue hemorrhagic fever (DF/DHF) is the most significant mosquito-borne viral disease affecting nearly 2.5 billion people living in more than 100 dengue endemic countries in the tropical regions. Moreover, dengue infection in adults has become an increasingly recognized problem, with the disease and clinical outcome being significantly different to those observed in children. There are no direct treatments, and progress in vaccine development has been slow because of the concerns with pathology surrounding antibody-dependent enhancement (ADE).
In this STOP Dengue proposal, the goal is to target zero death from dengue infection in Singapore adults, through Clinical Dengue Research that will lead to the optimization of early diagnosis, prognosis and case management for adult dengue infection, based on evidence derived from Molecular Pathogenesis studies of adult dengue diseases; as well as refining disease prevention strategies through the development of high-resolution epidemiological and entomological surveillance; and building the infrastructure to fast-track the evaluation of antiviral, therapeutic antibodies and low-cost vaccines as they become available for testing in patients.
This STOP Dengue Translational Research will harness the available clinical and scientific resources to establish infrastructures favorable for world class dengue research and clinical trials facilities. The approach will ultimately directly lead to reduced dengue disease burden in Singapore, with implications for other parts of the world as well. Since there is no precedent for a dengue treatment or vaccine, the proposed work is groundbreaking and thus carries with it all the risks that such an enterprise entails.
A fully professional team consisting of clinicians and scientists collaborating under 5-year old framework established under the Singapore Dengue Consortium makes this a truly national effort to translate clinical and epidemiological observations into improved molecular understanding of dengue disease leading to novel therapeutics/vaccines and cost-effective disease prevention.
TCR Infectious Disease - STOP Dengue Programme Executive Group