Applying For Grants
Approved Projects in FY2010
| Project Number | Project Title | Inst | Name |
| NMRC/1243/2010 | Implantation of autologous gene-modified bone marrow-derived mesenchymal stromal cells in pigs: Pre-clinical development of insulin-secreting bioimplants for diabetes therapy. | NCC | Kon, Oi Lian |
| NMRC/1244/2010 | Surveillance of More Virulent and Drug-Resistant Influenza A Strands in Singapore by High-Throughput Mass Spectrometry | NTU | Tang, Kai |
| NMRC/1245/2010 | Understanding Molecular Mechanism of Supradamal, a Novel Adamantanyl-Based Antimalarial Drug | NTU | Yoon, Ho Sup |
| NMRC/1246/2010 | Novel targeting of central growth regulation in malignant gliomas | NCC | Wong, Meng Cheong |
| NMRC/1247/2010 | The molecular epidemiology of influenza in a tropical country | NUH | Tang, Julian Wei-Tze |
| NMRC/1249/2010 | The Singapore Malay Eye Study 2 (SiMES-2) - Propective cohort study of 6-year incidence, risk factors, and impact of major Asian Eye Diseases | SERI | Wong, Tien Yin |
| NMRC/1253/2010 | Role of macrophage and dendritic cell lineages in immunity against Mycobacterium tuberculosis | NTU | Ruedl, Christiane |
| NMRC/1254/2010 | Understanding the specific roles of p53 and p44(p47) in regulating tumorigenesis | NCC | Sabapathy, Kanaga |
| NMRC/1255/2010 | Involvement of the forebrain theta network of structures in acute and chronic pain | NUS | Khanna, Sanjay |
| NMRC/1256/2010 | Identification of cell-associated and soluble mediators that modulate the inflammatory microenvironment in classical Hodgkin Lymphoma | NUS | Lim, Yaw Chyn |
| NMRC/1257/2010 | The purification and use of FGF-2-binding heparan sulfate to increase the healing of critical-sized bone defects | NUS | Hui, James Hoi Po |
| NMRC/1258/2010 | Novel Approaches to Promote Vascular Regeneration and Tissue Healing in Orthopaedic Surgery Via Biomaterial Functionalization | NUS | Wang, Ee Jen Wilson |
| NMRC/1259/2010 | Identification of Prognostic Biomarkers for Hepatocellular Carcinoma | NUS | Chung, Ching Ming Maxey |
| NMRC/1260/2010 | Suppression of AMPK as a novel cancer chemotherapeutic strategy via inhibition of autophagy | NUS | Shen, Han Ming |
| NMRC/1261/2010 | Statistical Methods for Secondary Analysis of Nested Case-Control Data | NUS | Salim, Agus |
| NMRC/1262/2010 | Immunology and immunopathology of influenza A infection | NUS | Kemeny, David Michael |
| NMRC/1263/2010 | Phase II Trial of Oxaliplatin/ Adriamycin/ 5 Fluorouracil in Continuous Infusion/ Interferon α-2b (OXAFI) combination as Neo-Adjuvant Therapy in Metastatic and Locally Advanced Unresectable Hepatocellular Carcinoma. AHCC0 protocol 08 | NCC | Chowbay, Balram |
| NMRC/1264/2010 | The quantification and physiological function of ergothioneine in vivo | NUS | Halliwell, Barry |
| NMRC/1265/2010 | Functional genomic analyses of human malaria parasite resistance to artemisinin | NTU | Bozdech, Zbynek |
| NMRC/1266/2010 | Identification and characterization of dengue virus receptors | Duke-NUS | Lok, Shee Mei |
| NMRC/1267/2010 | Role of stress granule components in Dengue virus propagation | Duke-NUS | Garcia-Blanco, Mariano A. |
| NMRC/1268/2010 | Generation of highly osteogenic bone tissue-engineered graft for treatment of fracture non-union – A Pre-Clinical to Phase I Study. | KKH | Chan, Kok Yen Jerry |
| NMRC/1269/2010 | Transcriptional Regulation of Ezh2 Expression in Immune Cells and Lymphoma | NTU | Su, I-hsin |
| NMRC/1270/2010 | Dietary fatty acids, oxylipins, and risk of coronary heart disease in Singapore Chinese | NUS | van Dam, Rob M. |
| NMRC/1271/2010 | Defining the mechanism of ?-glutamyl transpeptidase-mediated pathogenesis in Helicobacter pylori-associated severe gastric diseases and the development of a potential diagnostic marker for the disease. | NUS | Ho, Bow |
| NMRC/1272/2010 | Key Drivers of Tumor Growth in Nasal Polyposis | NUS | Wang, De Yun |
| NMRC/1273/2010 | Development of novel anti-HIV-1/AIDS drugs targeting host-viral protein interactions based on a unique high-throughput screening platform using the cell-free protein synthesis system | NUS | Yamamoto, Naoki |
| NMRC/1274/2010 | Stimulation of cardiac Na+/K+ ATPase with its antibody - A novel approach to treat chronic heart failure | NUS | Bian, Jinsong |
| NMRC/1275/2010 | Non- Invasive Evaluation of Chronic Allograft Nephropathy (CAN)/ Interstitial Fibrosis and Tubular Atrophy (IFTA) in Renal Transplants with Advanced Magnetic Resonance Imaging Techniques | NUS | Venkatesh, Sudhakar Kundapur |
| NMRC/1276/2010 | Promoting effective lymphatic drainage of the arteries as a new therapeutic intervention for atherosclerosis | NUS | Angeli, Veronique |
| NMRC/1277/2010 | A comprehensive evaluation of circulating tumour cells as a predictive marker of therapeutic response in renal cell carcinoma | NCC | Teh, Bin Tean |
| NMRC/1278/2010 | Linking BRAF/KRAS mutations and the CpG island methylation phenotype by methylome sequencing | NUS | Soong, Richie Chuan Teck |
| NMRC/1279/2010 | Reduction in hemorrhagic transformation by RNA interference from microRNAs upon tissue plasminogen activator (tPA) treatment of ischemic stroke | NUS | JEYASEELAN, Kandiah |
| NMRC/1280/2010 | Effect of topical application of encapsulated PPARbeta/delta agonist GW501516 microparticles, with two release kinetics, on cutaneous wound healing in diabetic mice -a preclinical animal study. | NTU | Tan, Nguan Soon |
| NMRC/1281/2010 | Targeting and eradicating human hepatocellular carcinoma cells in vivo with bone marrow-derived human mesenchymal stem cells transduced with oncolytic measles virus. | NCC | Hui, Kam Man |
| NMRC/1282/2010 | Role of Th2 cytokines in dysregulation of cholesterol metabolism in nephrotic syndrome: Modulation of SREBP and OSM-mediated pathways in an IL-13 overexpression model of minimal change nephropathy | NUS | Yap, Hui Kim |
| NMRC/CSA/016/2010 | Singapore Heart Failure Outcomes and Phenotypes | NUHS | Lam, Su Ping Carolyn |
| NMRC/CSA/017/2010 | Eliminating chronic myeloid leukaemia stem cells by targeting protein post-translational modification | SGH | Chuah, Charles Thuan Heng |
| NMRC/CSA/018/2010 | Elucidation of the Roles of CAAX Proteins That Mediate the Antitumor Efficacy of Cysmethynil, Novel Icmt Inhibitor | Duke-NUS | Wang, Mei |
| NMRC/CSA/019/2010 | Individualizing doses and predicting drug-drug interactions for anti-cancer and anti-HIV medications metabolized by UDP-glucuronosyltransferases | NUHS | Lee, Lawrence Soon-U |
| NMRC/CSA/020/2010 | Phase III Multi-Centre Open-Label Randomized Controlled Trial of Selective Internal Radiation Therapy versus Sorafenib in Locally Advanced Hepatocellular Carcinoma. AHCC protocol 06. |
SGH | Chow, Kah Hoe Pierce |
| NMRC/CSA/021/2010 | Translational pipeline: Developing novel therapeutics for cancer treatment, including the role of histone deacetylase inhibitors | NUHS | Goh, Boon Cher |
| NMRC/CSA/022/2010 | Clinical Phenotypes of Persistent Rhinitis in Young Children (0-5years) and the Role of Respiratory Viral Infections– A Prospective Evaluation of a Birth Cohort | NUH | Shek, Lynette Pei Chi |
| NMRC/CSA/023/2010 | Development and application of sustained drug release technology for the delivery of nucleic acid molecules for the prevention of post-operative scarring in glaucoma. | SERI | Wong, Tina |
| NMRC/CSA/024/2010 | Determining The Relative Importance of Modifiable Factors Affecting Survival From Out-Of-Hospital Cardiac Arrest In Singapore And The Cost-Effectiveness Of Strategies To Improve Outcomes. | SGH | Ong, Eng Hock Marcus |
| NMRC/CSA/025/2010 | Deciphering the interaction between dengue immune complex and monocytes in antibody-mediated immunity and disease enhancement. | Duke-NUS | Ooi, Eng Eong |
| NMRC/EDG/0079/2010 | Autologous cord blood cells for brain injury in term newborns | NUH | Lee, Jiun |
| NMRC/EDG/1000/2010 | Development of a novel mouse model of Enterovirus 71 infection | NUS | Alonso, Sylvie |
| NMRC/EDG/1001/2010 | Colony forming liver regeneration mediated in an injectable cell-laden hydrogel based phase transfer cell culture system | NTU | Wang, Dongan |
| NMRC/EDG/1002/2010 | Conducting Polymer Scaffold and Interface for Electrically Stimulated Osteogenesis | NUS | Neoh, Koon Gee |
| NMRC/EDG/1003/2010 | A novel closed-loop, double-vasopressor infusion system for strict control of arterial pressure to improve perioperative outcome and to predict the risks of developing abnormal blood pressure due to adrenoreceptor genetic polymorphisms during anaesthesia. | KKH | Sia, Tiong Heng, Alex |
| NMRC/EDG/1004/2010 | Identifying Potential Biomarkers Functionally Linked to t(4;14) Multiple Myeloma Using Plasma Membrane Proteomics | NUS | Chng, Wee Joo |
| NMRC/EDG/1005/2010 | Derivation of induced pluripotent stem cells from the reprogramming of human adipose-derived mesenchymal stem cells | NUS | Lim, Susan |
| NMRC/EDG/1006/2010 | Sequence variations of genes in the estrogen pathway and perinatal depression | KKH | Tan, Ene Choo |
| NMRC/EDG/1007/2010 | Photoactivable gene silencing using upconverting fluorescent nanoparticles for treatment of Malignant melanoma | NUS | Zhang, Yong |
| NMRC/EDG/1008/2010 | Investigation of the therapeutic effects of soluble IL-18 decoy receptor in keloid scars | NUS | Phan, Toan Thang |
| NMRC/EDG/1009/2010 | Gene expression profile of solute carrier (SLC) transporters and their roles in the uptake of antiretroviral drugs across human T4 lymphocytes | NUS | Lee, Edmund Jon Deoon |
| NMRC/EDG/1010/2010 | Evaluation of the anti-cancer function of autophagy in a zebrafish liver cancer model | NUS | Shen, Han Ming |
| NMRC/EDG/1011/2010 | Mesenchymal stem cell therapy for acute lung injury | KKH | Chan, Jerry |
| NMRC/EDG/1012/2010 | Epigenetic regulation of muscle differentiation | NUS | Taneja, Reshma |
| NMRC/EDG/1013/2010 | Evaluation and screening of scorpion sodium channel toxins for potential antitumor activity. | NUS | Bay, Boon Huat |
| NMRC/EDG/1014/2010 | Identification of Cancer-Associated Sequence Variations in Ultra-Conserved Genes | Duke-NUS | Voorhoeve, P. Mathijs |
| NMRC/EDG/1015/2010 | Quorum-Based Technology: Developing Anti-Virulence Therapeutics Targeting Gram-Positive Bacterial Pathogens. | NUS | Yew, Wen Shan |
| NMRC/EDG/1016/2010 | A biomaterial strategy to prevent Acinetobacter biofilm formation | NUS | Chua, Kim Lee |
| NMRC/EDG/1017/2010 | Basic characterization of a panel of neutralizing monoclonal antibodies targeting the hemagglutinin (HA) of the H5N1 influenza A virus: assessment of the potential for development as reagents for passive immunotherapy. | NUS | Tan, Yee Joo |
| NMRC/EDG/1018/2010 | Design and synthesis of small molecules that target nuclear co-repressor (N-CoR) protein in acute promyelocytic leukemia | NUS | Go, Mei Lin |
| NMRC/EDG/1019/2010 | Inflammation and effect of statins on retinal microvascular structure in TNF-alpha induced and spontaneous diabetic mouse model - novel understanding and treatment for diabetic retinopathy | SERI | Barathi, Veluchamy Amutha |
| NMRC/EDG/1020/2010 | Multifunctional folic acid-tagged nano-core-shells for targeting and treatment of epithelial ovarian cancer | NUS | Wang, John |
| NMRC/EDG/1021/2010 | The putative mammalian siderophore – a potential novel therapeutic target for neuroinflammation and neurodegenerative disease | NUS | Dawe, Gavin Stewart |
| NMRC/EDG/1022/2010 | Colorful Genetics To Illuminate Stem Cell Dynamics In The Mammary Gland | NCC | PIETERSEN, Alexandra |
| NMRC/EDG/1023/2010 | Streptococcus bovis: incidental or opportunistic pathogen in colon cancer | SGH | Ling, Khoon Lin |
| NMRC/EDG/1024/2010 | An Exploratory Randomized Controlled Trial of a Novel Family-Based Intervention to increase Outdoor Time for the Prevention of Myopia and Increase Physical Activity among Singapore Youth | NUS | Saw, Seang Mei |
| NMRC/EDG/1025/2010 | MICRORNA EXPRESSION SIGNATURES OF BREAST CANCER PATIENTS AND THEIR POTENTIAL AS DIAGNOSTIC AND PREDICTIVE TOOLS | NCC | Lee, Siew Gek Ann |
| NMRC/EDG/1026/2010 | Project to study the potential use of emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) for the treatment of hepatocellular carcinoma in vitro and in vivo | NUS | Sethi, Gautam |
| NMRC/EDG/1027/2010 | Elucidation of the role of microRNA in the pathogenesis of atopic dermatitis | NSC | Pramono, Zacharias Aloysius Dwi |
| NMRC/GMS/1248/2010 | A striatal synaptic dysfunction hypothesis for repetitive behaviors in autism evaluated by re-sequencing of candidate genes | Duke-NUS | Rozen, Steven George |
| NMRC/GMS/1250/2010 | Identification of novel tumor suppressors in the p53 pathway by combining hypothesis-driven statistical analysis of genomic tumor data with functional loss of function screens. | Duke-NUS | Voorhoeve, P. Mathijs |
| NMRC/GMS/1251/2010 | Evolutionary genomics of the 2009 swine-origin H1N1 influenza A pandemic virus | Duke-NUS | SMITH, Gavin James D |
| NMRC/GMS/1252/2010 | GADD34 in Insulin Synthesis and Beta-Cell Survival | Duke-NUS | Shenolikar, Shirish |
| NMRC/NIG/0087/2010 | Exploring repetitive Transcranial Magnetic Stimulation to improve gait disorder in Vascular Parkinsonism. | NNI | Yip, Chun Wai |
| NMRC/NIG/1008/2010 | Seroproteome analysis of Enterovirus 71 | NUS | Tan, Eng Lee |
| NMRC/NIG/1009/2010 | In vitro Hair Follicular Unit Reconstitution with Natural Appearance and Functions by Tissue Engineering Method | NUS | Kang, Lifeng |
| NMRC/NIG/1010/2010 | Platelet Gene Expression Profiling of Patients with Poor Response to P2Y12 Receptor Inhibition | NUH | Chan, Mark Yan Yee |
| NMRC/NIG/1011/2010 | Lumbar spinal canal stenosis: Expression and functional investigations on a library of different chondroitin sulphate molecules in normal and hypertrophic ligamentum flavum | CGH | Lee, Haw Chou |
| NMRC/NIG/1012/2010 | Effect of fibrin glue (Tissel) on human Endothelial cell morphology for harvesting of Descemet’s membrane/endothelium for transplantation |
SERI | Mehta, Jodhbir Singh |
| NMRC/NIG/1013/2010 | Combined transcranial direct current stimulation and motor imagery-based robotic arm training for stroke rehabilitation - a feasibility study. | NUH | Chew, Effie |
| NMRC/NIG/1014/2010 | Investigating role of electrical subthalamic and pallidal stimulation of the brain on the expression of GDNF family of ligands and GFRα receptor splice isoform and neurogenesis | NNI | Ng, Wai Hoe |
| NMRC/NIG/1015/2010 | Dual-compartmental growth factor delivery to achieve periodontal tissue regeneration | NUS | Chang, Po-Chun |
| NMRC/NIG/1016/2010 | Measuring optic disc tilt objectively with a new software with the scanning laser ophthalmoscope, Heidelberg Retinal Tomograph | NUH | Loon, Seng Chee |
| NMRC/NIG/1017/2010 | Elucidating Potential Lipid-Based Biomarkers in Schizophrenia | IMH | Lee, Chee Keong Jimmy |
| NMRC/NIG/1018/2010 | Bioengineering Hybrid Antifungal Molecules Based on Naturally Occurring Carbazoles for Eye Infection | SERI | Liu, Shouping |
| NMRC/NIG/1019/2010 | Retinal Microvascular Changes in Optic Neuropathy Subtypes: Investigating Vascular Mechanisms Underlying Optic Nerve Disorders. | SNEC | Fong, Audra Mei Yee |
| NMRC/NIG/1020/2010 | Identification and Evaluation of Novel Ribosomally-synthesized Antimicrobial Peptides (RAMPs) for Ocular Infections | SERI | Lakshminarayanan, Rajamani |
| NMRC/NIG/1021/2010 | Development and evaluation of a novel, dual mode, wide-field, ocular digital imaging technology for evaluation of angle closure | SERI | Baskaran, Mani |
| NMRC/NIG/1022/2010 | Association of placental syncytiotrophoblast membrane micro-particles with maternal immune response in recurrent pregnancy loss. | NUHS | Sheila, Vasoo |
| NMRC/NIG/1023/2010 | Does a mutation at the KCNQ1 locus that confers susceptibility to type 2 diabetes mellitus also cause QT abnormalities in patients with type 2 diabetes mellitus? | NUHS | Khoo, Chin Meng |
| NMRC/NIG/1024/2010 | A phase II trial of preoperative concurrent chemotherapy and intensity modulated radiotherapy (IMRT) in locally advanced rectal cancer | NUHS | Tey, Jeremy Chee Seong |
| NMRC/NIG/1025/2010 | A photoactivation imaging approach to unravel the role of Disrupted in Schizophrenia 1 (DISC1) in axonal transport and neuronal polarization | Duke-NUS | Lim, Kim Buay, Liz |
| NMRC/NIG/1026/2010 | The Role of Immune Monitoring in Predicting Acute and Chronic Complications Among Renal Transplant Recipients | NUH | Ng, Yue-Harn |
| NMRC/NIG/1027/2010 | Interleukin-1 Receptor Antagonist (IL-1ra): A Novel Therapeutic Approach for Corneal Inflammation | SERI | CHAURASIA, SHYAM S. |
| NMRC/NIG/1028/2010 | Derivation of patient-specific dopaminergic neurons via induced Pluripotent Stem Cells for molecular dissection of Parkinson’s Disease | Duke-NUS | Chai, Chou |
| NMRC/NIG/1029/2010 | A Randomised Controlled Trial of Cabergoline Prophylaxis for Ovarian Hyperstimulation Syndrome in IVF Cycles and Derivation of Biomarkers for OHSS. | KKH | Sybille, Hendricks Marianne |
| NMRC/NIG/1030/2010 | Adaptation and divergence of H1N1/2009 influenza A virus under controlled experimental conditions | Duke-NUS | Bahl, Justin |
| NMRC/NIG/1031/2010 | A study to delineate the relationship between obesity and bone mass/architecture. | SGH | Ng, Choong Meng Alvin |
| NMRC/NIG/1032/2010 | Exploring biomarkers as risk factors for cardiovascular disease in paediatric chronic kidney disease | NUH | Thong, Wen Yi |
| NMRC/NIG/1033/2010 | Improving Radiotherapy using 4D Magnetic Resonance Imaging and Visualization | NTU | Poh, Chueh Loo |
| NMRC/NIG/1034/2010 | Mechanisms of pattern recognition and immune response in invasive aspergillosis | NUH | Chai, Louis |
| NMRC/NIG/1035/2010 | The genetic determinants of Age Related Macular Degeneration in Asian populations – a comparative genetic study between three major Asian ethnic groups [Chinese, Indians and Malays] in Singapore. | SERI | Cornes, Belinda Kate |
| NMRC/NIG/1036/2010 | Preferences for care at the end-of-life among middle-aged and older Singaporeans | Duke-NUS | Malhotra, Chetna |
| NMRC/NIG/1037/2010 | Augmentation of liver regeneration and liver support in extended liver resections and small for size liver. | NUH | Iyer, Shridhar Ganpathi |
| NMRC/NIG/1038/2010 | Role of Thymosin-β4 in enhancing function and survival of endothelial progenitor cells in diabetes mellitus | NUH | Poh, Kian Keong |
| NMRC/NIG/1039/2010 | Functional characterization of aberrantly spliced Cav1.2 channels during cardiovascular development | NNI | Liao, Ping |
| NMRC/STaR/0008/2010 | Cell Therapy of Cancer | NUS | Campana, Dario |