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Ministry of Health   Singapore Government
National Medical Research Council  
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Approved Projects in FY2006

Project Number Project Title Inst Name
NMRC/1028/2006 Isolation And Characterization Stem Cells From Human Endometriotic And Endometrial Tissues SGH Tay, Sun Kuie
NMRC/1029/2006 In vitro and in vivo study of Ribosomal S6 kinase (RSK) in metastasis of breast cancer cells SGH Zhang, Kai
NMRC/1030/2006 Identification and functional characterization of mutations and/or polymorphisms in FAT10 gene to elucidate the role of these mutations/ polymorphisms in the carcinogenesis process NCC Lee, Caroline Guat Lay
NMRC/1031/2006 Rescue From Liver Failure by Novel Mitochondria-targeting Drugs NUS Boelsterli, Urs Alex
NMRC/1032/2006 Halting neurodegeneration through the selective inhibition of aberrant Cyclin dependent kinase 5 hyperactivity in vivo NUS Kesavapany, Sashitherapany
NMRC/1033/2006 The role of brain tumuor stem cells in radioresistance of malignant gliomas NCC Kang, Khong Bee
NMRC/1034/2006 Sleep Disorders in Parkinson's Disease: A Clinical, Polysomnographic and Case-Control Study NNI Lim, Li Ling
NMRC/1035/2006 Development of New Procedures for Corneal Transplantation and Corneal Surgery Using a Femtosecond Laser - Human Eye Bank Corneal Studies SERI Tan, Tiang Hwee Donald
NMRC/1036/2006 Role of Lipid Mediators, Leukotriene B4 and Lipoxin A4, as Inflammatory and Immune Modulators in Hodgkin Lymphoma NUS Lim, Yaw Chyn
NMRC/1037/2006 The interactive responses between metastatic lung cancer cells and activated microglia - To study the mechanism involved in brain metastasis, dormancy and relapse of cancer cells NUS He, Beiping
NMRC/1038/2006 Impact of stress on symptoms and underlying immunologic mechanisms of allergic rhinitis NUS Wang, De Yun
NMRC/1039/2006 Altered molecular regulation of cholesterol metabolism in an IL-13 gene overexpression model of minimal change-like nephropathy NUS Wei, Changli
NMRC/1040/2006 The role of dengue virus non-structural protein 1 (NS1) in the pathogenecity of the dengue virus infection NUS Ng, Mah Lee Mary
NMRC/1041/2006 Molecular and functional characterization of the preligand assembly domain in the cytokine receptor CD137 NUS Schwarz, Herbert
NMRC/1042/2006 Dengue vaccine: use of Lactococcus lactis as a live oral and nasal delivery system NUS Alonso, Sylvie
NMRC/1043/2006 Role of microRNAs in liver cirrhosis and liver regeneration NUS Tan, May Chin Theresa
NMRC/1044/2006 Sources of Conjunctival Stem Cells SERI Beuerman, Roger W.
NMRC/1045/2006 Chemotherapy of quiescent brain tumor stem cells NCC Wong, Meng Cheong
NMRC/1046/2006 Gene and protein profiling and the selection of limbal stem cell markers SERI Li, Jing
NMRC/1047/2006 Optimising Human hepatocytes from marginal livers for cellular therapeutics NUH Dan, Yock Young
NMRC/1048/2006 The detection of early nasopharyngeal carcinoma using a screening programme for siblings of affected patients. NUS Loh, Kwok Seng
NMRC/1049/2006 Prevalence of drug Resistance HIV-1 Patients with Seroconversion and recent infections in Singapore TTSH Lee, Cheng Chuan
NMRC/1050/2006 Office and Ambulatory Blood Pressure Norms in Singapore Children NUH Quek, Chaey Moon
NMRC/1051/2006 Research and Implementation of Biofeedback Gait Rehabilitation Device for Spinal Cord Injury (SCI) and Post-Stroke People NTU Low, Kin Huat
NMRC/1052/2006 Pathological Tremor Modeling and Active Compensation via Functional Electrical Stimulations NTU Ang, Wei Tech
NMRC/1053/2006 Mitochrondial dynamics and cell death NUS Armstrong, Jeffrey S.
NMRC/1054/2006 Nerve regeneration in different types of nerve conduits compared: Clinical, histological and histochemical outcomes in an animal model NUH Tan, Ter Chyan
NMRC/1055/2006 Screening of mitochondrial mutations in children with non-syndromic hearing loss NUS Tay, Kiat Hong Stacey
NMRC/1056/2006 Response Shift in Quality of Life in Chinese Breast Cancer Patients NUS Ng, Tze Pin
NMRC/1057/2006 Signaling mechanism for the vasorelaxant effect of hydrogen sulphide NUS Bian, Jinsong
NMRC/1058/2006 Investigating the anti-oncogenic and oncogenic roles of gelsolin in the development of tumours NUS Yap, Celestial Therese
NMRC/1059/2006 Interaction of amyloid precursor protein (APP) with sodium channels NUS Dawe, Gavin Stewart
NMRC/1060/2006 Screening patients with diabetes mellitus for latent and clinically overt tuberculosis infection: a preliminary prevalence study in a local tertiary hospital TTSH Leow, Melvin Khee Shing
NMRC/1061/2006 Novel therapeutic potential of endogenous hydrogen sulphide modulation in erectile dysfunction NUS Adaikan, P. Ganesan
NMRC/1062/2006 A 1-year prospective neuroimaging study of genetic variation in cortical dopamine influencing working memory prefrontal dynamics in first-episode schizophrenia NUS Tan, Hao Yang
NMRC/1063/2006 Muscle derived stem cells (MDSCS) for limb lengthening in rabbit model NUS Hui, James Hoi Po
NMRC/1064/2006 Alternative novel approaches for the production of tissues from human embryonic stem cells (hESCs) for transplantation and cancer therapy NUS Bongso, Ariff
NMRC/1065/2006 The influence of the vascularity and intrinsic permeability of the cartilaginous endplate on normal and degenerate discs in animal models of intervertebral disc compression and distraction NUS Hee, Hwan Tak
NMRC/1066/2006 Biocompatibility and Antimicrobal Activity of Orthopaedic Implant Biomaterials with Novel SurfaceModifications NUS Wang, Ee Jen Wilson
NMRC/1067/2006 Hypertension genes in Chinese adults with obesity and the metabolic syndrome (HYGENE-COMS) NUS Oh, Vernon Min Sen
NMRC/1068/2006 Functional and Molecular Analysis of C/EBPalpha Gene Knock-In Hepatocytes to Characterize Altered and Improved Attributes that May Be Beneficial in Bioartificial Livers NUS Hooi, Shing Chuan
NMRC/1069/2006 Expression of poor prognostic markers in matched primary and metastatic breast tissue NUH Lau, Philip Tsau Choong
NMRC/1070/2006 Head and Neck Squamous Cancer Stem Cells: Radio- and Chemoresistance, and Transcriptional Differences in Pathways Involved in Cancer Stem Cell Renewal NCC Ranjiv, Sivanandan
NMRC/1071/2006 Pathogenesis of the Intestinal Protozoan Parasite Blastocystis: Effects on Intestinal Mucosa and Barrier Function, and Characterization of Virulence Factors NUS Tan, Kevin Shyong Wei
NMRC/1072/2006 Analysis of PINK1 Gene Expression and Function SHS Tan, Eng King
NMRC/1073/2006 Randomized Phase II trial of concurrent chemo-radiotherapy with or without induction Gemcitabine, Carboplatin and Paclitaxel for Stage III and IV Nasopharyngeal Cancer NCC Wee, Joseph Tien Seng
NMRC/1074/2006 Retinal Photography in acute ischemic stroke patients: Clinical utility and yield NNI Chang, Hui Meng
NMRC/1075/2006 Lung Cancer in Singapore Chinese women: genetic determinants of susceptibility to inflammation and estrogen-related risk factors NUS Seow, Ling Hui Adeline
NMRC/1076/2006 Evaluation of role of microglia activation in chemotherapy-evoked painful peripheral neuropathy NUH Siau, Chiang
NMRC/1077/2006 A study to decipher survival pathways involved in the resistance of cancer cells to apoptotic death induced by the inhibition of Pi3K and to develop a computer-aided model of tumor progression NUS Clement, Marie-Veronique
NMRC/1078/2006 Modification of Blo t 5, a major Blomia tropicalis allergen, for a safer and effective specific immunotherapy for house dust mite allergy NUS Yi, Fong Cheng
NMRC/1079/2006 Development of a Homogeneous Assay Platform Generally Applicable to the Molecular Diagnosis of Dynamic Mutation Disorders NUS Chong, Samuel Siong-Chuan
NMRC/1080/2006 Enhancing enrichment of fetal primitive erythroblasts from maternal blood using antibodies against newly identified unique membrane proteins NUS Choolani, Mahesh A
NMRC/1081/2006 Predictive biomarkers of metastasis in breast cancer NUS Bay, Boon Huat
NMRC/1082/2006 Further Development and Experimental Trials of a Robotic System to Enhance Therapeutic GI Endoscopic Procedures NTU Phee, Soo Jay Louis
NMRC/1083/2006 Community Acquired Methicillin-resistant S. aureus and Penicillin non-susceptible S. pneumoniae carriage in healthy children attending day care centres NUH Tambyah, Paul Anatharajah
NMRC/1084/2006 Noninvasive prenatal testing using cell-free fetal DNA from the maternal plasma to exclude the fatal Hb Bart's hydrops fetalis inherited from alpha thalassaemia carriers of the common Southeast Asia (SEA) deletion amongst Southeast Asians. NUS Biswas, Arijit
NMRC/1085/2006 Evaluation of the allergenicity of Candida albicans and Cladosporium herbarum by nasal challenge NUS Chao, Siew Shuen
NMRC/1086/2006 Validation of surrogate measures in Irritable Bowel Syndrome, IBS: Experimental measures of pain, functional MR-imaging and endogenous pain modulation in IBS: correlations with clinical disease activity with and without medication NUS Ho, Khek-Yu
NMRC/1087/2006 CT Prediction of Treatment Response in Bone Metastasis NUS Lee, Taeyong
NMRC/1088/2006 Identification, cloning and functional expression of mitochondrial ADP-ribosyl cyclase from rat brain NUS Chang, Chan Fong
NMRC/1089/2006 Diabetic and post traumatic neuropathic pain, and possible interactions of nociceptin, nocistatin, their precursor and 7B2CT for new treatments and pain markers NUS Liu, Eugene Hern Choon
NMRC/1090/2006 Arterial stiffness among ischemic stroke patients with intracranial stenosis NNI De Silva, Deidre Anne
NMRC/1091/2006 Regeneration of Infarcted Myocardium using 3-Dimensional Tissue Scaffolds of Cardiomyocyte-like Cells Derived from Adult Human Bone Marrow Stem Cells NHC Shim, Winston Se Ngie
NMRC/1092/2006 A study of the effect of intraperitoneal hyperthermic chemotherapy on locally advanced gastric carcinoma SGH Wong, Wai Keong
NMRC/1093/2006 Structure/Function analysis of p53 in vivo - "knock-in" mouse models to study the role of p53 in carcinogenesis NCC Sabapathy, Kanaga
NMRC/1094/2006 Measurement of Visceral Adipose Tissue in Chinese, Malay and Indians SGH Wai, Daniel Chun Hang
NMRC/1095/2006 Minimally invasive nasopharyngectomy with the da Vinci Surgical System - a cadaveric study SGH Tay, Hin Ngan
NMRC/1096/2006 CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) Study) NNI Chen, Li Hsian Christopher
NMRC/1097/2006 Cytokine-induced killer (CIK) cell adoptive immunotherapy for AML and MDS SGH Linn, Yeh Ching
NMRC/1098/2006 Strategy for therapy in myotonic dystrophy (DM1): Correction of expanded CUG repeats in mutant DMPK gene transcripts in DM1 cell lines NNI Yee, Woon Chee
NMRC/1099/2006 Spot prevalence of antibiotic resistance in Singapore hospitals, and evaluation of in-vitro antibiotic synergy in multi-resistant gram-negative bacilli using a pharmacodynamic model CGH Tan, Thean Yen
NMRC/CSI/0006/2006 Prospective study of Magnetic Resonance Diffusion Tensor Tractography in patients with vascular gait disorders: Topographical correlation SGH Chan, Ling Ling
NMRC/CSI/0007/2006 Obesity Gene Study (OGS): uncovering genetic variations which predispose to human obesity and obesity-related complications NUS Lee, Yung Seng
NMRC/CSI/0008/2006 Liver Epithelial Progenitor cells and their therapeutic potential NUH Dan, Yock Young
NMRC/CSI/0009/2006 To develop reliable and robust biomarkers in breast cancer chemotherapy through high-throughput proteomic profiling NUH Lee, Soo Chin
 
Last Updated :  25 May 2010 23:55