| Project No |
Project Title |
PI |
Department |
Institution |
| NMRC/0712/2002 |
The natural history of prostatic disease and the selection of patients with symptomatic benign prostatic hyperplasia for different modalities of treatment |
Foo Keong Tatt |
Urology |
SGH |
| NMRC/0711/2002 |
Singapore breast cancer screening project part 2 - Validating absolute breast cancer risk prediction with the modified Gail model and health behaviour of subjects 8 years later |
Ang Peter Cher Siang |
Medical Oncology |
NCC |
| NMRC/0710/2002 |
Pathogen recognition and signaling by toll-like receptors, a family of adjuvant receptors for the host immune system to sense different types of pathogens |
Lu Jinhua |
NUMI |
NUS |
| NMRC/0709/2002 |
C-C chemokines in inflammation: Acute pancreatitis versus sepsis |
Bhatia Madhav |
Pharmacology |
NUS |
| NMRC/0708/2002 |
Ubiquitination activity and gene expression profile in Parkin gene mutations |
Tan Eng King |
|
SHS |
| NMRC/0707/2002 |
Distal radioulnar joint reconstruction - 4 strand technique: Cadaveric evaluation of load bearing ability and range of movement |
Lim Beng Hai |
Orthopaedic Surgery |
NUS |
| NMRC/0706/2002 |
Development of an intramedullary fixation device for metacarpal shaft fractures |
Lim Beng Hai |
Orthopaedic Surgery |
NUS |
| NMRC/0705/2002 |
Anatomy and biomechanics of the radial side of the thumb metacarpophalangeal joint: An Asian perspective to radial instability of the metacarpophalangeal joint of the thumb |
Looi Kok Poh |
Hand and Reconstructive Microsurgery |
NUH |
| NMRC/0704/2002 |
The role of gastric mucosa cyclo-oxygenase and prostaglandin in the pathogenesis of gastroduadenitis and ulcer disease in uremic patients |
Ho Khek Yu |
Medicine |
NUS |
| NMRC/0703/2002 |
The effects of graft enhancement using autologous mesenchymal stem cells on osteointegration and the minimum graft length of hamstring tendon grafts in a porcine model of anterior cruciate ligament reconstruction |
Hui James Hoi Po |
Orthopaedic Surgery |
NUS |
| NMRC/0702/2002 |
A prospective study of vascular cognitive impairment in Singaporean stroke patients: ESPRIT (European&Australasian Stroke Prevention in Reversible Ischaemia Trial) |
Chen Christopher Li-Hsian |
|
NNI |
| NMRC/0701/2002 |
Islet Transplantation for Type I diabetes using the Edmonton Protocol |
Calne Roy |
Surgery |
NUS |
| NMRC/0700/2002 |
Novel strategies to improve the efficacy of antibacterial and adjunctive therapies of acute and chronic bacterial infections |
Taylor Mark Buchanan |
Microbiology |
NUS |
| NMRC/0699/2002 |
Biochemical characterization of cubic membrane transition in amoeba Chaos and alternative model systems |
Deng Yuru |
Physiology |
NUS |
| NMRC/0698/2002 |
A novel prime boost DNA - protein vaccination strategy in combination with photodynamic therapy to optimize cancer vaccine potency employing a universal cancer antigen: telomerase catalytic subunit (hTert) |
Toh Han Chong |
Medical Oncology |
NCC |
| NMRC/0697/2002 |
Quantitative detection of aberrantly methylated p16CDKN2, O-6-methylguanine-DNA methyltransferase and E-cadherin gene (CDH1) in the serum of colorectal cancer patients - A prospective exploration for a new panel of biomarkers in colorectal cancers |
Liu Yanqun |
Colorectal Surgery |
SGH |
| NMRC/0696/2002 |
The effects of thyroid stimulation blocking antibodies on TSH-recptor expression, cAMP generation and adipogenesis in orbital fibroblasts |
Khoo Daphne |
Endocrinology |
SGH |
| NMRC/0695/2002 |
Changes in the Refractive Components in Myopia and Emmetropic Eyes: A Two-centre Study |
Saw Seang Mei |
|
SERI |
| NMRC/0694/2002 |
Perinatal Exposure To Organochlorine Pesticides and Polychlorinated Biphenyls in Singapore |
Mongelli Joe Max |
O&G |
NUS |
| NMRC/0693/2002 |
Characterization and evaluation of the functional significance of the unpregulated DEC-1 gene in children with steriod-responsive nephrotic syndrome (SRNS) in relapse |
Yap Hui Kim |
Paediatrics |
NUS |
| NMRC/0692/2002 |
Characterization of molecular events involved in the immunosuppressive action of PX-3.102 - a bioactive extract from a Chinese Herb |
Yap Hui Kim |
Paediatrics |
NUS |
| NMRC/0691/2002 |
A Multi-centre, Randomised, Controlled Study Comparing Nadroparin Calcium (Fraxiparine) 3,800 Axa iu/0.4ml Twice Daily with Aspirin 160mg Once Daily for the Treatment of Acute Ischaemic Stroke (FISS-tris Study) |
Chen Christopher Li-Hsian |
|
SGH |
| NMRC/0690/2002 |
Objective perimetry in poorly co-operative subjects: The development of a standardised testing system |
Lim Boon Ang |
|
SERI |
| NMRC/0689/2002 |
Urine analysis for prognostic indicators of response to therapy in bladder cancer patients receiving intravesical BCG instillations |
Esuvaranathan Kesavan |
Surgery |
NUS |
| NMRC/0688/2002 |
Evaluating the motor control concept of stability before mobility among subjects with shoulder dysfunction |
Rajaratnam Bala S. |
Physiotherapy |
Nanyang Polytechnic |
| NMRC/0687/2002 |
Investigation of Vascular Endothelial Growth Factor (VEGF) and Vascular Endothelial Growth Factor Receptor (VEGFR) expression in osteoarthritic articular cartilage |
Wang Ee Jen Wilson |
Orthopaedic Surgery |
NUS |
| NMRC/0686/2002 |
Prospective randomised study of the use of traditional Chinese medication compared with hemorrhoidectomy for hemorrhoids |
Ooi Boon Swee |
Colorectal Surgery |
SGH |
| NMRC/0685/2002 |
A pilot randomised controlled trial of the effectiveness and safety of campath as an induction agent for prevention of graft rejection and preservation of renal function in patients receiving cadaveric kidney transplants |
Vathsala A |
Renal Medicine |
SGH |
| NMRC/0684/2002 |
Studies in animal models of Type II diabetes bioactive compounds from Morinda officinalis and Pereskia grandifolia with effects on blood glucose, lipids and antioxidant levels |
Tan Kwong Huat, Benny |
Pharmacology |
NUS |
| NMRC/0683/2002 |
Crossing the histocompatibility barriers using transient immunosuppression: Implications in cellular cardiomyoplasty using human skeletal myoblasts for cardiac repair |
Haider Khawaja Husnain |
|
NUMI |
| NMRC/0682/2002 |
Molecular characterization of mutant DAX-1 protein in X-linked adrenal hypoplasia congenita: A study of 3 novel mutations |
Loke Kah Yin |
Paediatrics |
NUS |
| NMRC/0681/2002 |
Indirected transplantaion of Mesenchymal stem cells into the hypoglossal nuclei after unilateral nerve avulsion - Prototype model for treating neurodegenrative diseases |
Tay Sam Wah Samuel |
Anatomy |
NUS |
| NMRC/0680/2002 |
Analysis of regulatory factors involved in neurotoxicity in neurodegenerative diseases |
Thameem Dheen S |
Anatomy |
NUS |
| NMRC/0679/2002 |
Study of neurotoxic potential of Ropivacaine using a percutaneous rat sciatic nerve block model |
Tan Tze Siong |
Anaesthesia |
NUH |
| NMRC/0678/2002 |
Characterization of clinically significant peptides present in human cerebrospaninal fluid (CSF) |
Tachibana Shinro |
Anaesthesia |
NUS |
| NMRC/0677/2002 |
Cardiac arrest and resuscitation epidemiology in Singapore: A prehospital study, phase II (CAREII) |
Lim Swee Han |
Emergency Medicine |
SGH |
| NMRC/0676/2002 |
Generation and characterization of human nasopharyngeal carcinoma cell lines |
Low Wong Kein |
ENT |
SGH |
| NMRC/0675/2002 |
Prevalence and clinical study of eating disorders in young females |
Ho Ting Fei |
Physiology |
NUS |
| NMRC/0674/2002 |
Influence of probiotics on atopy, atopic disease and immunological responses - A randomised double-blind, placebo-controlled clinical trial |
Shek Lynette Pei Chi |
Paediatrics |
NUS |
| NMRC/0672/2002 |
Vitrification of hepatocyte spheroids and encapsulated hepatocytes |
Yu Hanry |
Physiology |
NUS |
| NMRC/0671/2002 |
The use of long wave ultrasound to upregulate endogenous bone morphogenetic proteins (BMP) and angiogenic factors (AF) in normal and irradiated bone |
Ho Kee Hai |
Dentistry |
NUS |
| NMRC/0670/2002 |
Prevention of neuronal death and seizure by the agonists and antagonists of metabotropic glutamate receptors in the animal model of status epilepticus. |
Tang Feng-Ru |
Epilepsy Research Lab |
NNI |
| NMRC/0669/2002 |
Cytotoxic T lymphocyte activities to hepatitis B virus in chronic hepatitis B patients infected with mild-type and HBeAg negative hepatitis B virus |
Chow Wan Cheng |
Gastroenterology |
SGH |
| NMRC/0668/2002 |
Studies on the anaphylatoxin activation of neutrophilis and macrophages through their C5a receptor |
Melendez Alirio J. |
Physiology |
NUS |
| NMRC/0667/2002 |
A community survey of elderly subjects with atrial fibrillation: associated risk factors and treatment preferences |
Yap Keng Bee |
Geriatric Med |
AH |
| NMRC/0666/2002 |
1) a study into the haemodynamic response of a local population of patients with liver cirrhosis to propranolol; 2) a study into the effect of lamivudine on portal pressures using invasive haemodynamic measurements |
Lui Hock Foong |
Gastroenterology |
SGH |
| NMRC/0665/2002 |
Tissue Engineering of Conjuctival Stem Cells |
Tan Tiang Hwee Donald |
|
SNEC |
| NMRC/0664/2002 |
Analysis of the levels of Nocistatin and Nociceptin, in animal models of chronic pain |
Lee Tat Leang |
Anaesthesia |
NUS |
| NMRC/0663/2002 |
Do noradrenergic mechanisms play a role in the cognitive effects of atypical antipsychotics? - A neuropsychological and fuctional magnetic resonance (fMRI) study |
Dawe Gavin Stewart |
Pharmacology |
NUS |
| NMRC/0662/2002 |
Prospective Comparison of Magnetic Resonance versus Echocardiography in the Detection of Cardiac Thrombi |
Tan Ru San |
Cardiology |
NHC |
| NMRC/0661/2002 |
Pulmonary Venous Anatomy in Patients with Focal Atrial Fibrillation Undergoing Radiofrequency Ablation: Assessment by Serial Magnetic Resonance Imaging |
Tan Ru San |
Cardiology |
NHC |
| NMRC/0660/2002 |
Myocardial Viability assessed by Magnetic Resonance Imaging versus Conventional Nuclear Methods |
Chua Terrance |
Cardiology |
NHC |
| NMRC/0659/2002 |
5-azacytidine induced cardiomycyte transformation of bone marrow derived mesenchymal stem cells and their therapeutic potential for the treatment of chronic myocardial infarction |
Sim Eugene, Kwang Wei |
Cardiac |
NUS |
| NMRC/0658/2002 |
Auto Transplantation of Mesenchymal Stem Cell into Chronically Failing Heart-Porcine Model |
Sim Eugene, Kwang Wei |
Cardiac |
NUS |
| NMRC/0657/2002 |
Single Nucleotide Polymorphins (SNPs) in the MDR1 gene in the three ethnic groups in Singapore - Correlating polymorphins/ haplotypes with drug transport in search of functional SNPs |
Chong Samuel S. |
Paediatrics |
NUS |
| NMRC/0656/2002 |
Loss of Immune Tolerance in Chronic Hepatitis B |
Lim Seng Gee |
Medicine |
NUS |
| NMRC/0655/2002 |
Towards a Bioartificial Kidney Device |
Sit Kim Ping |
|
NUS |
| NMRC/0654/2002 |
The prevalence of large exon rearrangements in the BRCA1 gene in Asian early onset and familial breast cancer patients |
Iau Philip Tsau Choong |
Sugery |
NUS |
| NMRC/0653/2002 |
Incidence of Chlamydia Pneumoniae Antibodies in patients with Abdominal Aortic Aneurysms in Singapore |
Teoh Ming Keng |
General Surgery |
SGH |
| NMRC/0652/2002 |
The Evaluation of the Isoprostane, 8-Epi-Prostaglandin F2a in Placental Pathophysiology |
Kwek Kenneth |
Maternal Fetal Medicine |
KKH |
| NMRC/0651/2002 |
Functional Studies of mutant melanocortin receptors due to novel mutations of the melanocortin-3 receptor gene and melanocortin-4 receptor gene causing obesity in humans |
Lee Yung Seng |
Paediatrics |
NUS |
| NMRC/0650/2002 |
Investigations into the neural circuitry underlying hippocampal nociceptive responses and its influence on formalin nociception, an animal model of persistent pain. |
Khanna Sanjay |
Physiology |
NUS |
| NMRC/0649/2002 |
Poor response to ovarian stimulation with follicle-stimulating hormone: possible genetic causes |
Roy Ashim C |
O & G |
NUS |
| NMRC/0648/2002 |
Correlation of Hepatitis B genotypes and Hepatocellular Carcinoma |
Ng Han Seong |
Gastroenterology |
SGH |
| NMRC/0647/2002 |
Insight and neuro-cognitive profile of first-episode psychosis patients in an Asian setting. |
Woo Matthew |
Psychology |
IMH |
| NMRC/0646/2002 |
Ecology of Legionella in Singapore |
Lee Yuan Kun |
Microbiology |
NUS |
| NMRC/0645/2002 |
Asia pacific acute myocardial infarction trial (APAMIT) - extended pilot study. |
Koh Tian Hai |
Cardiology |
NHC |
| NMRC/0644/2002 |
Investigate superoxide anion dependent survival pathway(s) in tumor cells |
Clement Marie-Veronique |
Biochemistry |
NUS |
| NMRC/0643/2002 |
Endothelium and smooth muscle interaction in coronary artery bypass grafts with implications in coronary surgery |
He Guo-Wei |
Surgery |
NHC |
| NMRC/0642/2002 |
Gene expression and colonization of lactic acid bacteria in gastrointestinal tract. |
Lee Yuan Kun |
Microbiology |
NUS |
| NMRC/0641/2002 |
Anxiety Disorders in Singapore: A Community Survey |
Chua Hong Choon |
IMH |
IMH |
| NMRC/0640/2002 |
Elucidation of structural regions involved in GFRalpha-2 (receptor) demerization and interaction wit the GDNF-like ligand neurturin |
Ranganathan Shoba |
Biochemistry |
NUS |
| NMRC/0639/2002 |
Epidemiological study of clostridium difficile infections in hospital and the community. |
Koh Tse Hsien |
Pathology |
SGH |
| NMRC/0638/2002 |
Further dissection of the role of the adenomatous polyposis coli (APC) gene and search for other candidate genes in the colorectal carcinomas (CRC) |
Cheah Peh Yean |
Colorectal Surgery |
SGH |
| NMRC/0637/2002 |
Functional Significance of Fas-FasL Pathway of Apoptosis in Normal and Malignant Trophoblasts |
Mongelli Joe Max |
O&G |
NUS |
| NMRC/0636/2002 |
Characterisation of mesenchymal stem cells isolated from animal and human tissues |
Hui James Hoi Po |
Orthopaedic Surgery |
NUS |
| NMRC/0635/2002 |
Nitric Oxide and peroxynitrite in ageing: Mediators of bone and cartilage damage in osteoporosis and osteoarthritis? |
Whiteman Matthew |
Biochemistry |
NUS |
| NMRC/0634/2002 |
The application of ultrasound based augmented reality with the directional vacuum-assisted breast biopsy device in the treatment of breast cancer |
Wee Siew Bock |
GS |
TTSH |
| NMRC/0633/2002 |
Evaluation of accuracy of non-invasive multi-detector spiral CT angiography against conventional angiography in coronary arterial disease. |
Seto Kar Yin |
Diagnostic Imaging |
NUH |
| NMRC/0632/2002 |
The Generation of Novel Monoclonal Antibodies to Tumor-Specific Antigens Expressed on Multiple Myeloma Cells |
Teoh Gerrard |
DCR |
SGH |
| NMRC/0631/2002 |
Design, application and validation of a novel computational model for population pharmacokinetic and pharmacodynamic modelling. |
Lee Edmund |
Pharmacology |
NUS |
| NMRC/0630/2002 |
Investigation of low wear rate sliding pair for loaded orthopaedic bearings |
Lo Ngai Nung |
Othopaedic surgery |
SGH |
| NMRC/0629/2002 |
Immunological and Biological Response of Myelodysplastic Marrow to Thalidomide |
Liu Te Chih |
Haematology/Oncology & Lab Medicine |
NUH |
| NMRC/0628/2002 |
Endothelial Progenitor Cells: A novel and promising cell vehicle for temporal-and-spatial-specific gene therapy |
Wong Meng Cheong |
|
NCC |
| NMRC/0627/2002 |
Cultivation and Characterization of Human Epidermal Stem Cells for Tissue Engineering of Epidermis and Living Composite Skin |
Lee Seng Teik |
Plastic Surgery |
SGH |
| NMRC/0626/2002 |
A prospective study to determine the significance of serological markers of previous Hepatitis B infection in patients with hepatocellular carcinoma |
Tan Chee Kiat |
Gastroenterology |
SGH |
| NMRC/0625/2002 |
Design and development of a system to apply hydrostatic pressure stimuli to regulate cell metabolism in cultures used in musculoskeletal tissue engineering |
Satkunanantham K |
Orthopaedics |
NUS |
| NMRC/0624/2002 |
Factor of safety in ligaments: a study of the physiological strains of ligaments relative to its ultimate load. |
Ashvin Thambyah |
Orthopaedic Surgery |
NUS |
| NMRC/0623/2002 |
Cardiovascular actions of angiotensin IV |
Sim Meng Kwoon |
Pharmacology |
NUS |
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